Hereditary spastic paraplegia (HSP) is a complex genetic/inherited/familial disorder that primarily affects/targets/impacts the motor neurons/nervous system/spinal cord. This progressive/deteriorating/evolving condition often presents/manifests/emerges with stiffness and weakness in the legs/lower limbs/thighs, making walking increasingly difficult
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Figure 1 displays the pedigrees of family members as well as the segregation of pathogenic variants in those family members the place causal genetic variants for HSP and HCA had been determined. it had been observed that folks of affected people today in people 1 to four practiced consanguineous marriages, though mom and dad of influenced folks in
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